MOTS-c — Mitochondrial-Derived Peptide
- HPLC ≥ 98% verified purity
- Lot-specific Certificate of Analysis
- 24-hour nationwide UK delivery
- Crypto (USDT) or Whop
- Free shipping over £100
- Cold-chain protected shipping
About MOTS-c
A 16-amino-acid peptide encoded within mitochondrial DNA — a master regulator of cellular energy metabolism.
MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded entirely within the mitochondrial genome — a rare example of a functional peptide derived from mitochondrial DNA rather than nuclear DNA. Discovered in 2015 at USC's Cohen Lab, MOTS-c has become a leading research target in mitochondrial biology and metabolic-aging science.
Unlike most peptides that act on cell-surface receptors, MOTS-c translocates between the mitochondria, cytoplasm, and nucleus, making it a unique signalling molecule that links mitochondrial status to nuclear gene expression.
Research mechanism
In published studies, MOTS-c has been shown to:
- Activate the AMPK pathway — the cell's master energy sensor, increasing fatty-acid oxidation and glucose uptake
- Modulate insulin sensitivity in skeletal muscle in rodent obesity and diabetes models
- Translocate to the nucleus and influence stress-response gene expression
- Reduce age-related metabolic dysfunction in aged mouse models
- Increase mitochondrial biogenesis and exercise capacity in published animal studies
Research applications
- Metabolic syndrome and insulin resistance research
- Mitochondrial biology and biogenesis studies
- Longevity and aging research models
- Skeletal muscle energy metabolism research
- AMPK signalling pathway investigation
- Exercise physiology and endurance research
Product specifications
Frequently asked questions
How is MOTS-c supplied?
Each REVIVE vial contains 10 mg of lyophilized MOTS-c at ≥ 98.0% HPLC purity with a lot-level COA. Stable at −20°C, desiccated.
How do I reconstitute MOTS-c?
Add 2–3 mL bacteriostatic water along the vial wall. Swirl gently. Refrigerate at 2–8°C after reconstitution.
Why is MOTS-c considered a "longevity" peptide?
In rodent studies, MOTS-c administration has been associated with improved insulin sensitivity, increased exercise endurance, and reduced age-related metabolic decline. The AMPK pathway it activates overlaps significantly with caloric-restriction and metformin pathways — both well-established in longevity research.
Do you ship MOTS-c across the UK?
Yes — same-day dispatch and 24h delivery to mainland UK. £8 delivery, free over £100. crypto or card via Whop.
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24-hour delivery to mainland UK · Crypto (USDT) or Whop · Free shipping over £100
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