IGF-1 LR3 1 mg — reference profile

What this compound is

IGF-1 LR3 is a recombinant analogue of insulin-like growth factor 1, modified by a 13-residue extension at the N-terminus and a substitution at position 3. Those changes reduce its affinity for IGF-binding proteins compared with native IGF-1.

Molecular profile

Composition: Recombinant IGF-1 analogue with a 13-residue N-terminal extension. Molecular weight ≈ 9111 Da.

Molecular weight is the figure used to confirm identity by mass spectrometry: the measured mass is compared against the value calculated from the sequence, and agreement within instrument tolerance is what establishes that the material is the intended molecule rather than merely a pure one.

What published research has examined

The literature examines receptor binding, binding-protein affinity and its consequences, cell-proliferation studies, and comparisons against native IGF-1 and other analogues.

This is a description of what has been studied, not a claim about outcomes and not a suggestion that anyone should use it. Research findings in cell culture or animal models do not transfer directly to any other setting.

Format and handling

Single vial of lyophilized material.

Supplied as a white lyophilized powder. Handled cold; solutions are not stored long.

Storage conditions and the expiry date on the label describe material kept as specified. A vial left at ambient temperature has not been stored as specified, whatever the date says.

Documentation and verification

Each batch carries a Certificate of Analysis stating purity, identity and the methods used. The outer box carries a printed RVL code which resolves against production records and returns the item, strength, batch number and dates.

The batch number should read the same on the vial, on the box and on the certificate. Where it does not, treat the material as undocumented until the discrepancy is explained.